Fictional character biography
Unlike most serial killers, Ghostface is not one specific person. Ghostface is an identity used by killers when they want to go on a killing spree. The killer puts on the Ghostface costume and he (or she) becomes Ghostface. Taking on the identity of Ghostface gives the person the ability to change his or her voice so that it cannot be recognized (indicating that the mask or masks likely come with attached voice modulators). Due to the fact that Ghostface is not specifically one person, his/her motive for killing can differ for each time he/she kills.
Ghostface was originally created by Billy Loomis in Scream to get revenge on the man his mother had an affair with. Following this, many others took on the Ghostface identity to kill.